The Role of miR-129-5p in Cancer: A Novel Therapeutic Target
- Resource Type
- Article
- Authors
- Xu, Shan; Li, Wei; Wu, Jing; Lu, Yuru; Xie, Ming; Li, Yanlan; Zou, Juan; Zeng, Tiebing; Ling, Hui
- Source
- Current Molecular Pharmacology; 2022, Vol. 15 Issue: 4 p647-657, 11p
- Subject
- Language
- ISSN
- 18744672; 18744702
miRNA-129-5p belongs to the microRNA-129 (miRNA-129) family. miRNA-129-5p is expressed in many tissues and organs of the human body, and it regulates a wide range of biological functions. The abnormal expression of miRNA-129-5p is related to the occurrence and development of a variety of malignant tumors. miRNA-129-5p plays an important role in the tumorigenesis process and functions by promoting or inhibiting tumors. However, the role of miRNA-129-5p in cancer remains controversial. This article reviews the different biological functions of miRNA- 129-5p in cancer and provides ideas for research in this field to guide the development of targeted therapies and drugs for malignant tumors.