In 2011, with the successful isolation of Ti3C2, a door of 2D layered MXene has been opened and received growing attention from researchers. MXene refers to a family of two-dimensional (2D) materials made up of atomic layers of the transition metal, carbide, nitrides, or carbonitrides. Given the large surface area, adjustable surface terminal groups, and excellent conductivity of MXene, it has shown exciting potential in photocatalysis, energy conversion, and many other fields. Among many 2D MXene, Ti3C2was the most studied for its availability, low cost, facile modification procedure, and outstanding electronic properties. In previous investigations, Ti3C2has shown huge potential in the photocatalysis area. Ti3C2in a photocatalysis system can enhance the separation of photoinduced electrons and holes, reduce charge recombination, and thus improve the photocatalysis performance in many systems. To adjust the performance of Ti3C2in different applications, the properties of Ti3C2including morphology, structures, and stability are tunable by different post-processing method in the hybridized materials. In this review, an all-around understanding of the fabrication and modification methods of Ti3C2and their connection to photocatalytic applications of Ti3C2MXene based materials are presented. Moreover, a summary and our perspectives of Ti3C2are given for further investigation.