We provide a floristic and taxonomic treatment of Ficussect. Americanaefor the Brazilian state of Acre. The section is represented in Acre by 30 species. Ficus dugandiiand F. pastasanaare reported from Brazil for the first time. We reestablish several species, among them F. regularis(previously considered a synonym of F. trigona) and F. mathewsiiand F. subapiculata(both previously considered subspecies of F. americana). Ficus acreanais treated here as a synonym of F. panurensis. We designate lectotypes for F. obtusifolia, F. pallida, and F. ypsilophlebia.