High-quality seismic data is key to determining the success or failure of oil and gas exploration in complex mountain fronts. Observation systems are important factors affecting the quality of the seismic collection. Currently, the seismic collection design of piedmont zones is mainly based on optimizing and analyzing a single collection parameter. The multiparameter optimization is not performed as a whole. Moreover, the collection parameters that significantly impact the imaging quality of piedmont zones are not deeply excavated. This paper first uses the relationship between the acquisition parameters and the signal-to-noise ratio of a previous seismic data analysis to solve this problem and then obtains the prestack offset profiles of different acquisition parameters through forward modeling and prestack offset methods, further analyzes the acquisition parameters that have a more significant impact on imaging quality, uses the degenerative treatment method to process and analyze the newly collected seismic data, and delves into the most sensitive acquisition parameters for imaging quality. The results show that the influence of the gun line distance is the largest, and the influence of the receiving line distance, the number of receiving lines, and the number of receiving channels is reduced. Therefore, the effect of each acquisition parameter on the imaging quality is different, and different acquisition parameters should be selected according to the depth of the target layer.