A device for securing and protecting a needle, the device comprising a first portion (3) and a second portion (5), each provided with an adhesive face covered in a detachable anti-adhesive sheet, the first portion (3) being for securing to the skin, in register with the penetration site selected for the needle, and the second portion (5) being for overlying the penetration site of the needle, the device being made of a flexible material and having a longitudinal slot (2) for passing the needle and a transverse bearing zone for the needle, with only one of the faces of the first portion (3) being adhesive, the second portion (5) being suitable and configured to be secured to the skin while overlying the needle penetration site and without being stuck to the first portion (3).