PURPOSE:: To evaluate clinical features and manifestations of Eales disease and the efficacy of different interventions. METHODS:: The databases PubMed, EMBASE, and Ovid from inception until February 2021 were searched. Pooled analyses included 1) presenting features 2) symptoms and signs 3) postoperative vision outcomes and complications. Statistical analyses were conducted with R software version 3.6.3. RESULTS:: 47 studies involving 3557 patients and 4959 eyes were included. The pooling results showed that Eales disease was male-dominated (94%), bilateral involvement (64%) and mainly occurred in adolescents. About 83% of patients were positive in Mantoux test, and 31% of patients have vitreous tap PCR positive for tuberculosis genome. More than half of the patients had decreased vision at the first clinic visit. The common signs of Eales disease included sclerotic vessels (83%), NVE (64%) and periphlebitis (51%). Macular changes could be detected in 24% of patients. The most common complication was VH, followed by cataracts and RD. Photocoagulation was directed at non-perfusion or neovascularization areas, with a decrease incidence of later PPV (19%). Anti-VEGF treatment was suggested for VH, which could achieve high VA improvement rate (82%) while increasing the possibility of RD (18%). PPV was indicated in cases with persistent VH or RD, with 56% of patients obtaining visual improvement. Still, 17% of patients needed a second PPV, mainly due to recurrent VH or RD. CONCLUSION:: Eales disease most commonly affects young men. It has diverse clinical features and management should be based on the progression of the disease.