BACKGROUND: The BioEnterics Intragrastric Balloon (BIB®) together with restricted diet has been used for the treatment of obesity and morbid obesity. METHODS: A prospective study was conducted on 100 patients who had undergone the BIB procedure between February 2005 and February 2007. RESULTS: Mean age, mean weight, and mean BMI of the patients were 35.35 ± 9.25 years, 113.23 ± 24.76 kg (range 73-200 kg), and 39.28 ± 6.98 kg/m (range 30-69.2 kg/m), respectively. Six months after the BIB procedure, mean weight and mean BMI were reduced to 100.46 ± 26.05 kg (range 58-178 kg) and 34.70 ± 11 kg/m (range 21.83-61.59 kg/m), respectively. There was a statistically significant reduction in weight and BMI at 6 months after the BIB procedure (p < 0.01). Excess weight loss (EWL) at 6 months ranged between 0 and 28 kg, with a mean value of 12.68 ± 7.70 kg. The subjects had 0 to 99.2% %EWL (mean 28.63 ± 19.29). Reduction in BMI at 6 months ranged between 0 and 12.3 kg/m, with a mean value of 4.51 ± 2.85 kg/m, and percent excess body mass index loss (%EBMIL) was 38.20 ± 28.78% (range 0-158%). At 6 months, there was a significant reduction in body weight and BMI (p < 0.01) in both groups. The reduction in BMI of the morbidly obese group was significantly greater than that of the obese group (p = 0.035), and both the %EWL and %EBMIL of the morbidly obese patients were significantly lower than those of the obese patients at 6 months (p = 0.001). CONCLUSIONS: BIB application is a reasonable weight loss method with few complications.