The hot deformation behavior of Ti–22Al–25Nb was studied by the high temperature compression over a range of temperatures (950–1050 °C) and strain rates (0.001–10 s−1) in this paper. The work-hardening (WH) and softening deformationbehaviors of Ti–22Al–25Nb were analyzed. Obvious linear decreasing regimes of WH rate curves can be found before thedynamic recrystallization (DRX) onset, which indicates WH+ DRV (dynamic recovery) stage. And WH rate decreasedsignifcantly with strain rate reduced and temperature elevated. A physically-based constitutive model was established,which can well predict the fow behavior of Ti–22Al–25Nb. Additional, strain-rate sensitivity coefcient distribution mapwas established. The higher values of m appeared at the low strain rate. When the strain rate exceeded 0.1 s−1, the values ofm were lower than 0.25.