A tapered As 2 S 3 photonic crystal fiber (PCF) with four layers of air holes in a hexagonal array around the core is designed in this paper. Numerical simulation shows that the dispersion D decreases and the nonlinearity coefficient γ increases from the thick to the thin end along the tapered PCF. We simulate the midinfrared pulse compression in the tapered As 2 S 3 PCF using the adaptive split-step Fourier method. Initial Gaussian pulses of 4.4 ps and a central wavelength of 2.5 μm propagating in the tapered PCF arelocated in the anomalous dispersion region. With an average power of assumed input pulses at 3 mW and a repetition frequency of 81.0 MHz, we theoretically obtain a pulse duration of 56 fs and a compression factor of 78 when the pulse propagates from the thick end to the thin end of the tapered PCF. When confinement loss in the tapered PCF is included in the simulation, the minimum pulse duration reaches 72 fs; correspondingly, the maximum compression factor reaches 61. The results show that in the anomalous-dispersion region, midinfrared pulses can be efficiently compressed in a dispersion-decreasing and nonlinearity-increasing tapered As 2 S 3 PCF. Due to confinement loss in the tapered fiber, the efficiency of pulse compression is suppressed.