Laser-metal inter gas (MIG) hybrid welding technique provides higher overall productivity over the traditional fusionwelding processes for joining medium-thick aluminum alloy. In this paper, laser-MIG hybrid welding experiment was performedby the TruDisk 12003 Laser and KUKA robot. The second fusion line, the laser-dominated region and laser-MIGhybrid-dominated region were introduced to this study to discuss the microstructure distribution. A three-dimensionalfinite element model was established by MSC. Marc to study the thermal field distribution of laser-MIG hybrid weldingprocess. It found that the temperature in the laser-MIG hybrid-dominated region was much higher than the laser-dominatedregion. The formation of the second fusion line in the welded joint is mainly owing to the different heat effect of laser-archybrid-dominated region and laser-dominated region. The crystalline size of equiaxed dendrite grains in the laser-MIGhybrid-dominated region is finer than the laser-dominated region. In addition, the tensile property was measured to dissectthe failure mechanism of the laser-MIG hybrid welding joints. The element content in fractured surface at the position ofdimple and pore wall were comprehensively analyzed. The element content of Mg and O in pore wall are higher than dimple. In the solidification process, the growth of equiaxed dendrite grains is in part hindered by the existence of coarse pores inthe laser-MIG hybrid-dominated region.