Layered double hydroxide nanosheets embedded β-cyclodextrin composite membranes with enhanced chiral separation performance
- Resource Type
- Article
- Authors
- Zhengzhong Zhou; Lingli Zhou; Yi Liu; Qian Wang; Xiaoshan Meng; Qigang Wu; Taoli Huhe
- Source
- Journal of Industrial and Engineering Chemistry, 128(0), pp.569-577 Dec, 2023
- Subject
- 화학공학
- Language
- English
- ISSN
- 1876-794X
1226-086X
The technologies for enantiomeric resolution are essential to the development of pharmaceutical industry. The membrane technology has great potential in chiral separation owing to its low cost and highthroughput; however, the enantioselective of membrane is limited by the thickness of the active layer,which is closely related to the number of theoretical separation plates. In this work, the layered doublehydroxides (LDH) are synthesized by hydrothermal process and then vacuum filtrated with bcyclodextrin(b-CD) and polyvinyl alcohol (PVA) on a porous substrate to fabricate chiral selective membranes. 2D channels with increased number of separation stages are formed in the selective layer afterheat post-treatment. The enantiomeric excesses value is enhanced from 10.95% to 24.32% for racemicL/D- tryptophan resolution. This work provides a new approach for designing high performance chiralseparation membranes from the aspect of increasing the transport path.