The removal of H2S that seriously threaten the environment and human health is of great significance inenhancing coal cleaning utilization. Herein, a series of persimmon wood-inspired macroporous (a%Co-Mn)1.5Al0.5Ox (a = 0, 3, 6, 10, 15, 20) sorbents were constructed by the self-assembly of vacuumassistedsol–gel procedure, and their desulfurization efficiency was evaluated on a fixed-bed reactor at600–800 C. Among cobalt-doping sorbents, the breakthrough sulfur capacity (BSC, 272.2 mg g1) andeffective utilization (EU, 81.5%) over (15%Co-Mn)1.5Al0.5Ox is greatly high than the value (138.08 mg g1)over ZnCoO4/SAPO-34@SBA-15, and slightly lower than BSC (286.2 mg g1) and EU (92.3%). The magnificationSEM images of (15%Co-Mn)1.5Al0.5Ox revealed that regularly straight macroporous channel structureinherited from persimmon wood effectively promoted the rapid diffusion of H2S molecules andaccelerated the rate of sulfur/oxygen exchange on the interface of the channel wall. In the meantime,the results studied by the deactivation kinetics model also confirm invariable rate constants (ka, kd) withhigh correlation coefficients due to higher stability and renewable ability of (15%Co-Mn)1.5Al0.5Ox.