Iron Single-Atom nanocatalysts in response to tumor microenvironment for highly efficient Chemo-chemodynamic therapy
- Resource Type
- Article
- Authors
- Tushuai Li; Li Chen; Xiao Fu; Zhihong Liu; Shenglong Zhu; Yongquan Chen; Jie Zhang
- Source
- Journal of Industrial and Engineering Chemistry, 112(0), pp.210-217 Aug, 2022
- Subject
- 화학공학
- Language
- English
- ISSN
- 1876-794X
1226-086X
Chemodynamic therapy (CDT) based on multifunctional nanoparticles (NPs) has occurred as an attractivecancer treatment that covers the shortage of nonnegligible limitations from single therapy. Herein, wesynthesize a safe and universal CDT nanoparticle—iron single-atom nanoparticle (Fe SANP), in whichFe single-atom as the active catalytic site is anchored in a carbon framework with encapsulated doxorubicin(DOX). Fe SANPs work as catalase-like nanozyme for hydroxyl radicals (OH) production. The preparedNPs (denoted as DOX@Fe SANPs) can efficiently mediate peroxidase-like activity with the existenceof H2O2 that enhances cancer cell elimination by generating abundant OH. DOX@Fe SANPs exhibit a pHinduceddegradable character that contributes to specific drug release in the tumor microenvironment(TME). DOX@Fe SANPs produce ignorable systematic toxicity after biodegradation and drug delivery processes. Collectively, this study highlights the efficient anti-tumor performances of the iron single-atomnanocatalysts containing an anti-cancer drug DOX.