The owner-led major project innovation management model has been proved by practice to be a very suitable organization management model for major innovation projects. As the leading party in the entire process of engineering innovation and project implementation, the owner is of great significance to how to effectively stimulate the willingness of the participating entities to cooperate in innovation and promote multi-party collaborative innovation. In this research, we conduct research on the major engineering innovation dynamic mechanism led by the owner and collaborative innovation of production, education and research, build a dynamic mechanism framework, analyze relevant factors and their role relationships, and give suggestions on the dynamic mechanism based on the analysis results.