To explore the relationship between seasonal influenza and the environment, the principal task is to make data on influenza and environment for effective management. This paper focuses on the design and implementation of spatial database system for seasonal influenza in mainland China. Firstly, it proposed the influential environmental factors for seasonal influenza and collected the influenza surveillance data from China Influenza Surveillance System and relevant environmental data by remote sensing as well as meteorological monitoring. Then, it introduced the schema and technological processes of influenza spatial database systems. It took ArcSDE and Oracle 9i as the database platforms and adopted three-layer development model. Finally, it realized the system by programming in the C# environment with ArcEngine. The database system provides uniform spatial reference for spatial analysis of seasonal influenza and environmental factors, which is a basis for influenza-environmental modeling and influenza epidemic early-alerting.