Fine particulate matter (PM2.5) induces the stem cell-like properties of hepatocellular carcinoma by activating ROS/Nrf2/Keap1-mediated autophagy
- Resource Type
- article
- Authors
- Jiujiu Li; Haoqi Jiang; Yu Zhu; Zijian Ma; Bin Li; Jun Dong; Changchun Xiao; Anla Hu
- Source
- Ecotoxicology and Environmental Safety, Vol 272, Iss , Pp 116052- (2024)
- Subject
- Fine particulate matter
Stemness
Hepatocellular carcinoma
Reactive oxygen species
Autophagy
Environmental pollution
TD172-193.5
Environmental sciences
GE1-350
- Language
- English
- ISSN
- 0147-6513
Exposure to fine particulate matter (PM2.5) has been linked to an increased incidence and mortality of hepatocellular carcinoma (HCC). However, the impact of PM2.5 exposure on HCC progression and the underlying mechanisms remain largely unknown. This study aimed to investigate the effects of PM2.5 exposure on the stem cell-like properties of HCC cells. Our findings indicate that PM2.5 exposure significantly enhances the stemness of HCC cells (p