Correlation of retinal layer changes with vision gain in diabetic macular edema during conbercept treatment
- Resource Type
- article
- Authors
- Yupeng Xu; Yuan Qu; Yan Suo; Jian Gao; Xia Chen; Kun Liu; Xun Xu
- Source
- BMC Ophthalmology, Vol 19, Iss 1, Pp 1-9 (2019)
- Subject
- Diabetic macular edema
Retinal layer thickness
Layer segmentation
Anti-VEGF
Conbercept
Ophthalmology
RE1-994
- Language
- English
- ISSN
- 1471-2415
Abstract Backgrounds To assess the changes in individual retinal layer thickness and visual function associated with gains in visual acuity after an intravitreal conbercept injection in the diabetic macular edema (DME) on spectral domain optical coherence tomography (SD-OCT) and microperimetry during 1-year follow-up. Methods Retrospective observational study. Twenty patients with clinically significant DME in the study eye were imaged by SD-OCT every 3 months and MP1 microperimeter in the third month while receiving anti-vascular endothelial growth factor (VEGF) (conbercept) treatment. In each patient, seven retinal layers were segmented in 98 scans covering a 6 mm × 6 mm area of the macula at baseline and during 1 year of treatment. An automatic, full-threshold microperimetry of the central field (10° × 10°, 40 stimulated points) with the MP1 microperimeter. Thickness and microperimetry changes were quantitatively measured and evaluated for their correlation with increases in visual acuity. Results Although thicknesses of the inner nuclear layer (INL) and the outer nuclear layer (ONL) were reduced the most after treatment (p