It is important to identify atmospheric environmental drivers of childhood asthma because asthma is the most common chronic disease in children globally. We provided an overview of the impacts of exposure to atmospheric environmental factors (e.g., meteorological factors and air pollutants) on childhood asthma, based on a series of studies with the cutting-edge environmental epidemiological methodology in Shanghai, China. Overall, we found that the prevalence of asthma among the children aged 3–7 years had increased by approximately 7 fold, from 2.1% in 1990 to 14.6% in 2019. Most meteorological factors (i.e. daily mean temperature, temperature difference, air pressure, air pressure difference, precipitation, relative humidity, sunshine and wind speed) and air pollutants (PM10, PM2.5, NO2, SO2 and O3) were significantly associated with childhood asthma (p