Fructo-oligosaccharide enhanced bioavailability of polyglycosylated anthocyanins from red radish via regulating gut microbiota in mice
- Resource Type
- article
- Authors
- Wenfeng Li; Wanjie Zhang; Xin Fan; Hai Xu; Hong Yuan; Yimeng Wang; Rui Yang; Hua Tian; Yinmei Wu; Hongyan Yang
- Source
- Food Chemistry: X, Vol 19, Iss , Pp 100765- (2023)
- Subject
- Fructo-oligosaccharide
Red radish anthocyanins
Bioavailability
Gut microbiota
Antioxidant activity
Nutrition. Foods and food supply
TX341-641
Food processing and manufacture
TP368-456
- Language
- English
- ISSN
- 2590-1575
The anthocyanins from red radish (ARR) rich in polyglycosylated pelargonidin glucosides were used as pigment. However, bioavailability of anthocyanins was considered at low level. This work examined the intensive effects of fructo-oligosaccharide (FOS) on ARR bioavailability. Pelargonidin, cyanidin and pelargonidin-3-glucoside showed higher level in serum of mice fed with FOS together with ARR for 8 weeks than that fed with only ARR. Co-ingestion of FOS and ARR more effectively elevated the hepatic antioxidant activity by increase in total antioxidant capacity and activities of superoxide dismutase and glutathione peroxidase when compared with intake of ARR. FOS also markedly increased pelargonidin level in cecum of mice. 16S RNA sequencing found that Bacteroides genus play an important role in FOS elevating bioavailability of ARR. Fecal bacteria transplantation verified the positive effects of FOS on ARR bioavailability. These results suggested that combined ingestion of FOS and ARR is effective strategy for bioactivity of ARR.