文章研究了经典名方程氏蠲痹汤(Cheng Shi Juan Bi Tang,CSJBT)对佐剂性关节炎(adjuvant arthri-tis,AA)大鼠的治疗作用.实验选取 SD大鼠,采用弗氏完全佐剂(complete Freund's adjuvant,CFA)建立AA大鼠模型,实验设立正常组、模型组、雷公藤多苷(glycosides of tripterygium wilfordii,GTW)组(0.01 g/kg)、CSJBT 3个剂量组(分别为2.55、5.10、10.20 g/kg)共6个组,考察CSJBT给药治疗14 d后,其对AA大鼠足肿胀度、脏器指数和血清免疫球蛋白水平的影响,并采用 HE染色法观察AA大鼠踝关节组织的形态学变化.结果显示CSJBT可缓解AA大鼠关节肿胀,降低血清Ig G水平,改善其关节组织的病理学变化,表明CSJBT对AA大鼠具有较好的治疗作用.
Therapeutic effects of Cheng Shi Juan Bi Tang(CSJBT)on adjuvant arthritis(AA)in rats were investigated.AA model was established by injecting complete Freund's adjuvant(CFA)into the hindpaw of SD rats.Rats were randomly divided into six groups:control group,AA model group, glycosides of tripterygium wilfordii(GTW)group(0.01 g/kg)and three different dosage groups of CSJBT(2.55 g/kg,5.10 g/kg,10.20 g/kg).After treated with CSJBT by intragastric administration for 14 d,the hindpaw swelling,organ indexes and levels of serum immunoglobulin were measured to evaluate the effects of CSJBT on AA rats.Morphologic changes of joints were observed by haematox-ylin-eosin(HE)staining method.The results showed that CSJBT could relieve the paw swelling of AA rats significantly and reduce Ig G level of serum obviously.It also improved the pathological chan-ges of joints.Therefore,CSJBT has good therapeutic effects on AA rats.