目的::探究金水六君煎与穴位敷贴联合治疗对慢性支气管炎患者血液流变学、炎症因子以及肺功能的影响机制,为慢性支气管炎患者的临床治疗提供相关帮助.方法:选取我院收治的120慢性支气管炎患者,随机分为治疗组和对照组各60例,对照组给予解痉、抗炎、平喘、吸氧以及化痰等基本治疗,治疗组在此基础上给予金水六君煎与穴位敷贴的联合治疗,治疗前后检测两组血液流变学、炎症因子以及肺功能情况.结果:治疗前两组血液流变学指标、炎症因子以及肺功能指标比较,差异无统计学差异(P >0.05);与治疗前相比,两组经过相关治疗后血液流变学相关指标(WHV、WLV、PV、PCV 以及RCAI)、炎症因子(IL-8以及 TNF-α)显著降低,肺功能相关指标(FVC、FEV1.0、PEF、MVV 以及V0.50)以及炎症因子(IL-4、IL-2)显著升高,差异具有统计学意义(P <0.05);治疗组经过联合治疗后患者肺功能相关指标(FVC、FEV1.0、PEF、MVV 以及 V0.50)以及炎症因子(IL-4、IL-2)显著高于治疗后对照组,血液流变学相关指标(WHV、WLV、PV、PCV 以及 RCAI)以及炎症因子(IL-8以及 TNF-α)显著低于治疗后对照组;组间差异存在统计学意义(P <0.05).结论:金水六君煎联合穴位敷贴显著改善了慢性支气管炎患者的血液流变学、炎症因子以及肺功能水平,对慢性支气管炎患者的治疗具有十分重要的临床意义.
[ABSTRACT]Objective:To investigate the influencing mechanism of Jin-Shui-Liu-Jun-Jian and acupoint application com-bined therapy on hemorheology,inflammatory factors and pulmonary functions in patients with chronic bronchitis,thus to of-fer relevant help for clinical therapies on patients with chronic bronchitis.Methods:A total of 120 patients with chronic bron-chitis treated in our hospital were selected and randomly divided to be the therapeutic group and the control group,with 60 ca-ses in each group.Both groups were given some basic treatments,such as spasmolysis,anti-inflammation,asthma relieving, oxygen inhalation and dissolve phlegm.And the therapeutic group was also given extra Jin-Shui-Liu-Jun-Jian and Acupoint Ap-plication combined therapy.Hemorheology,inflammatory factors and pulmonary functions in the two groups of patients were detected before and after treatment.Results:Differences in hemorheology indexes,inflammatory factors and pulmonary func-tion relevant indexes between the two groups of patients with chronic bronchitis before treatment showed no statistical signifi-cance (P > 0.05 ).Compared with those before treatment,hemorheology relevant indexes (WHV,WLV,PV,PCV and RCAI),inflammatory factors (IL-8 and TNF-α)were significantly decreased and pulmonary function relevant indexes (FVC, FEV1.0,PEF,MVV and V0.50),inflammatory factors (IL-4,IL-2)were significantly increased in the two groups of patients with chronic bronchitis after relevant treatments.The differences between the groups showed statistical significance (P <0.05). After treatment,pulmonary function relevant indexes (FVC,FEV1.0,PEF,MVV and V0.50)and inflammatory factors (IL-4,IL-2)in therapeutic group were significantly higher than that of control group.Hemorheology relevant indexes (WHV, WLV,PV,PCV and RCAI)and inflammatory factors (IL-8 and TNF-α)in therapeutic group were significantly lower than control group;Differences between the two groups showed statistical significance (P <0.05).Conclusion:Combination of Jin-Shui-Liu-Jun-Jian and acupoint application significantly improved the levels of hemorheology,inflammatory factors and pulmo-nary functions in patients with chronic bronchitis.It has a great important clinical significance on therapies for patients with chronic bronchitis.