We present constraints on local primordial non-Gaussianity (PNG), parametrized through $f^{\rm loc}_{\rm NL}$, using the Sloan Digital Sky Survey IV extended Baryon Oscillation Spectroscopic Survey Data Release 14 quasar sample. We measure and analyze the anisotropic clustering of the quasars in Fourier space, testing for the scale-dependent bias introduced by primordial non-Gaussianity on large scales. We derive and employ a power spectrum estimator using optimal weights that account for the redshift evolution of the PNG signal. We find constraints of $-51Comment: 28 pages, 12 figures. Comments welcome!