The interfacial structure and dynamics of water in a microscopically confined geometry is imaged in three dimensions and on millisecond time scales. We developed a 3D wide-field second harmonic microscope that employs structured illumination. We image pH induced chemical changes on the curved and confined inner and outer surfaces of a cylindrical glass micro-capillary immersed in aqueous solution. The image contrast reports on the orientational order of interfacial water, induced by charge-dipole interactions between water molecules and surface charges. The images constitute surface potential maps. Spatially resolved surface pKa,s values are determined for the silica deprotonation reaction. Values range from 2.3