Objective: Orthodontics, as a common way of orthodontic treatment, is usually to maintain oral health and protect periodontal tissue. The self-ligating appliance technique, since its advent in the 1930s, have been rather popular ammong the majority of orthodontists. This study was to determine that self-ligating appliance can reduce inflammation in gingival crevicular fluid (GCF) of patients receiving orthodontic treatment and keep periodontal health. Methods: The clinical data of 97 orthodontic patients admitted to the Department of Stomatology of Fujian Provincial Hospital, Fujian Provincial Clinical College of Fujian Medical University from March 2019 to March 2020 were analyzed retrospectively. Among them, 42 patients receiving orthodontic treatment with traditional MBT straight-wire appliance (SWA) were included in the control group (CG) and 55 patients treated with self-ligating appliance were collected as the observation group (OG). The two cohorts were compared with respect to the following aspects: curative effect, pain degree on the 1st, 2nd, 3rd, 5th and 7th day after wearing the appliance, oral related quality of life (QoL) before and after orthodontic treatment, satisfaction with the orthodontic treatment, periodontal condition, and GCF and inflammatory factor contents before, 3 months and 6 months after orthodontic treatment. Results: OG had significantly higher therapeutic efficacy of orthodontic treatment than CG (P