Androgen receptor promotes oral squamous cell carcinoma cell migration by increasing EGFR phosphorylation
- Resource Type
- Authors
- Xin, Liu; Shanglan, Qing; Keke, Che; Lihua, Li; Xiaoming, Liao
- Source
- OncoTargets and therapy
- Subject
- oral squamous cell carcinoma
stomatognathic diseases
phosphorylation
androgen receptor
EGFR
migration
Original Research
- Language
- ISSN
- 1178-6930
Objectives: This study is aimed to investigate the role of androgen receptor (AR) in regulating oral squamous cell carcinoma (OSCC) cells migration. Materials and methods: Tumors from 23 patients with OSCC and five OSCC cell lines were used for analyzing AR expression. The effects of AR agonist and antagonist were used to examine the role of AR in regulating the migration of OSCC cells. Results: Ten of 23 tumors from patients with OSCC were AR positive. There was no significant difference in total EGFR (tEGFR) expression between AR-positive tumors and AR-negative tumors. However, the expression of phosphorylated EGFR (pEGFR) in AR-positive tumors was significantly higher than that in AR-negative tumors (p