FLAIR3Phase: a new synthetic MRI contrast for paramagnetic rim lesions detection in multiple sclerosis
- Resource Type
- Authors
- Vanden Bulcke, Colin; Delinte, Nicolas; Macq, Benoît
- Source
- Proc. Intl. Soc. Mag. Reson. Med. 31 (2023), (19 May 2023)
- Subject
- Multiple Sclerosis
Multi-Contrast
Imaging Biomarker
Paramagnetic Rim Lesions
MRI
- Language
- English
Chronic active multiple sclerosis (MS) lesions are visible on susceptibility-based MRI as paramagnetic rim lesions (PRL); these lesions are characterized by severe tissue damage and strongly correlate with disease severity. PRL assessment is usually performed manually on unwrapped-filtered phase images. However, PRL assessment is associated with high intra/inter-rater variability due to the poor visibility of PRL and to the lack of standardized imaging protocols/guidelines for their detection. Here, we propose a new synthetic contrast called FLAIR3Phase to augment PRL assessment workflow and to reduce rater variability.