Anal squamous cell carcinoma in a high HIV prevalence population
- Resource Type
- Authors
- Christopher C. Khoo; Irene Chong; Sarah Mills; Christos Kontovounisios; Oliver Warren; Diana Tait; Mark Bower; Gianluca Pellino; Paris P. Tekkis; Danielle R L Brogden
- Source
- Europe PubMed Central
Hormones & Cancer
- Subject
- HPV
Cancer Research
medicine.medical_specialty
CANCERS
Endocrinology, Diabetes and Metabolism
Population
Disease
GUIDELINES
Endocrinology & Metabolism
03 medical and health sciences
0302 clinical medicine
Endocrinology
Anal squamous cell carcinoma
Surgical oncology
COLON
Internal medicine
MANAGEMENT
Medicine
1112 Oncology and Carcinogenesis
education
education.field_of_study
Science & Technology
Endocrine and Autonomic Systems
business.industry
Research
Incidence (epidemiology)
Anal Squamous Cell Carcinoma
HIV
MEN
Retrospective cohort study
Chemoradiotherapy
Oncology
030220 oncology & carcinogenesis
Cohort
030211 gastroenterology & hepatology
business
Life Sciences & Biomedicine
- Language
- ISSN
- 2730-6011
Anal Squamous Cell Carcinoma (ASCC) is a rare cancer that has a rapidly increasing incidence in areas with highly developed economies. ASCC is strongly associated with HIV and there appears to be increasing numbers of younger male persons living with HIV (PLWH) diagnosed with ASCC. This is a retrospective cohort study of HIV positive and HIV negative patients diagnosed with primary ASCC between January 2000 and January 2020 in a demographic group with high prevalence rates of HIV. One Hundred and seventy six patients were included, and clinical data was retrieved from multiple, prospective databases. A clinical subgroup was identified in this cohort of younger HIV positive males who were more likely to have had a prior diagnosis of Anal Intraepithelial Neoplasia (AIN). Gender and HIV status had no effect on staging or disease-free survival. PLWH were more likely to develop a recurrence (p