Longitudinal variance of Donor‐Derived Cell‐Free DNA (dd‐cfDNA) in Stable Kidney Transplant (KTx) patients are influenced by donor/recipient variables
- Resource Type
- Authors
- Donald Morris; Jorge Sanchez-Garcia; Titte R. Srinivas; Sanjiv Anand; Jake Krong; Li Dong; Fidel Lopez-Verdugo; Megan Fife
- Source
- Clinical Transplantation. 35
- Subject
- Graft Rejection
Transplantation
Univariate analysis
medicine.medical_specialty
business.industry
Significant difference
Urology
Kidney Transplantation
Kidney transplant
Tissue Donors
Post transplant
Cell-free fetal DNA
Bayesian multivariate linear regression
Humans
Biomarker (medicine)
Medicine
Donor derived
business
Cell-Free Nucleic Acids
- Language
- ISSN
- 1399-0012
0902-0063
BACKGROUND The longitudinal time-course of dd-cfDNA after kidney transplant (KTx) is not well-described. The cut off values of dd-cfDNA in KTx derive from biopsy-coupled single measurements. Meaningful interpretation necessitates understanding of: (1) time variance of dd-cfDNA levels post-KTx, (2) factors determining biologic variability, and (3) relationship to donor and recipient characteristics. We hypothesized that an understanding of the aforementioned factors would better inform clinical decision-making using dd-cfDNA. METHODS One hundred and twenty five KTx patients with dd-cfDNA obtained longitudinally were included. Univariate analyses were directed at inter-patient variability and intra-patient inter-occasion variability of dd-cfDNA. Multivariate linear regression was used in analyses accounting for repeat measures. RESULTS At 1-month post KTx median dd-cfDNA: (1) were higher in repeat KTx (.57%, P