Major Histocompatibility Complex Class I-related Chain A and B Gene Expression in Sepsis Patient
- Resource Type
- Authors
- Sule Menziletoglu Yildiz; Ersel Güleç; Dilek Özcengiz; Gulizar Atli; Birol Guvenc
- Source
- Subject
- 0301 basic medicine
Stress induced
Expression
Biology
Major histocompatibility complex
medicine.disease
Gene
Sepsis
03 medical and health sciences
stomatognathic diseases
030104 developmental biology
0302 clinical medicine
Chain (algebraic topology)
030220 oncology & carcinogenesis
Major Histocompatibility Complex Class I-related Chain A and B
Gene expression
Immunology
Genetics
biology.protein
medicine
Genetics (clinical)
Function (biology)
- Language
- English
WOS: 000402784000004 Major histocompatibility complex class I-related chain A and B (MICA/B) function in the regulation of protective responses due to stress induced expression. One of the major causes of the morbidity is sepsis. The objective of this study was to measure the mRNA levels of these genes in the control and sepsis patient groups. Data showed increases in mRNA concentrations of MICA and MICB in the Patient Group in contrast to the Control Group. However this level was found higher than MICA mRNA concentration in the patient group. The current study is the first report according to the researchers' knowledge representing the significant increases in the MICA and MICB expressions in the sepsis. This might provide a useful data for emphasizing these molecules as sensitive biomarkers. Further research is needed to enlighten the detail mechanisms of the MICA/B roles and to develop new treatment approaches.