Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years
- Resource Type
- Authors
- Nouzha Bouamoud; Ismail Kaarouch; Brahim Saadani; Moncef Benkhalifa; Aicha Madkour; Said Assou; Saaïd Amzazi; Smahane Aboulmaouahib; Omar Sefrioui; Henri Copin; Noureddine Louanjli
- Source
- Molecular Reproduction and Development
Molecular Reproduction and Development, Wiley, 2018, 85 (3), pp.271-280. ⟨10.1002/mrd.22963⟩
- Subject
- Adult
Male
0301 basic medicine
advanced paternal age
sperm quality
Pregnancy Rate
[SDV]Life Sciences [q-bio]
medicine.medical_treatment
education
Aneuploidy
Semen
DNA Fragmentation
Fertilization in Vitro
Biology
Paternal Age
Miscarriage
Andrology
03 medical and health sciences
0302 clinical medicine
Pregnancy
Genetics
medicine
Humans
In Situ Hybridization, Fluorescence
Infertility, Male
Genome
030219 obstetrics & reproductive medicine
In vitro fertilisation
Age Factors
Pregnancy Outcome
Paternal age
Embryo
Cell Biology
Middle Aged
medicine.disease
Spermatozoa
Sperm
in vitro fertilization outcomes
Semen Analysis
030104 developmental biology
sperm genome decays
DNA fragmentation
Female
Developmental Biology
- Language
- ISSN
- 1040-452X
1098-2795
International audience; This study assessed sperm quality declining on relation to paternal age and its impact on in vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff. For this, 83 couples undergoing IVF treatment for male factor infertility were enrolled. The women age was ≤39 years, whereas the men were divided in two groups: APA (n = 41; age ≥ 40 years) and young (Y) (n = 42; age