Background: Cancer related pain is a significant & growing problem for those living with & surviving cancer, requiring biopsychosocial (BPS) management independent to treatment of underlying disease. Best practice pain management has been established in the field of chronic non cancer pain (CNCP), starting with education that is grounded in pain science. Consideration of this approach for cancer related pain management is scarce, yet there is strong rationale for its use. The aim of this study was to explore the use of pain science in explaining cancer related pain to patients through education, facilitating communication of a BPS phenomenon. Methods: An exploratory narrative review was used to unveil a practice in its inception & deepen understanding of the field (Greenhalgh et al. 2018). All relevant literature was identified using 7 target concepts of pain education (search completed June ’21). A descriptive synthesis of findings was interpreted & critiqued. Methodological quality was included to assess the impact on findings, not as criteria for exclusion. Results: Pain science education is poorly established in the cancer pain management literature. 8 studies (4 RCTs, 2 pilot, 2 feasibility) met the inclusion criteria. Study sample sizes of 9-127, 238 unique participants, 112 received targeted pain education. Conclusive findings from a small evidence base of variable design & quality were limited, but positive individual outcomes provide rich detail for clinical application & a plausible basis for further research. Conclusions: To the author’s knowledge, this is the first review to explore the use of pain science in explaining cancer related pain to patients through education. It provides a basis to illuminate this field & focus & develop the evidence base for clinical practice. A biomedical model continues to dominate the management of cancer related pain when an evidence base exists for reconceptualising & communicating a BPS phenomenon through high quality education. The evidence base represents some progress, but is in its inception. The future potential could be significant. Acknowledgements and Disclosures of Interest(s): The authors report no competing interests to declare, nor funding associated with this work.