Differential expression of leukemia inhibitory factor and insulin like growth factor-1 between normal pregnancies, partial hydatidiform moles and complete hydatidiform moles
- Resource Type
- Authors
- Ayse Nur Cakar; Emine Rümeysa Hekimoğlu; Ozge Senem Yucel Cicek; Mehmet Sinan Beksac; Mert Turgal; Pergin Atilla; Alp Usubutun
- Source
- Placenta. 69:64-70
- Subject
- Adult
0301 basic medicine
endocrine system
Placenta
medicine.medical_treatment
Leukemia Inhibitory Factor
Fetal Development
Andrology
Young Adult
03 medical and health sciences
Insulin-like growth factor
0302 clinical medicine
Pregnancy
Somatomedins
medicine
Humans
Decidual cells
Insulin-Like Growth Factor I
reproductive and urinary physiology
Partial Hydatidiform Mole
030219 obstetrics & reproductive medicine
urogenital system
Chemistry
Decidua
Obstetrics and Gynecology
Trophoblast
Hydatidiform Mole
Insulin-Like Growth Factor
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
Uterine Neoplasms
embryonic structures
Chorionic villi
Female
Chorionic Villi
Leukemia inhibitory factor
Immunostaining
Developmental Biology
- Language
- ISSN
- 0143-4004
Introduction Leukemia inhibitory factor (LIF) and insulin like growth factor-1 (IGF-1) are two of the most important growth factors mediating trophoblast actions. We hypothesized that the localization and expression patterns of LIF and IGF-1 in partial and complete hydatidiform moles (HM) compared with normal first trimester placentas may provide an understanding of the proliferative processes in HMs. Methods The study population included curettage material of women diagnosed as complete or partial HM as a result of histopathological and immunohistochemical examination (complete HM group, n = 8; partial HM group, n = 8) and women undergoing dilatation&curettage for unwanted pregnancies (control group, n = 8). Expression of LIF and IGF-1 among placental cell groups was evaluated immunohistochemically and given a score depending on immunostaining intensity. Results In normal chorionic villi strong expression of LIF and IGF-1 was present. Both LIF and IGF-1 expressions were weaker in the chorionic villi of complete HMs. In complete mole decidua there was a significant decrease in glandular and endothelial IGF-1 expression along with a decrease in decidual cell LIF expression compared to normal first trimester decidua. LIF expression in extravillous trophoblasts was stronger in complete molar placentas compared to normal placentas. Discussion LIF and IGF-1 are important regulators of trophoblast proliferation and invasion. Differential expression of LIF and IGF-1 in molar trophoblasts and chorionic villi might have a role in regulation of trophoblasts in complete moles. Decreased expression of glandular IGF-1 and decidual LIF might be related to the decidual changes during trophoblastic proliferation and invasion of decidua in complete HMs.