Enhanced histone deacetylase enzyme activity in primary myelofibrosis
- Resource Type
- Authors
- Chi Chen; Jen-Chin Wang; Jack Burton; Thong Chang; Inna Sominsky; Ying Yi Xiao; Theresa Dumlao; Seema Naik
- Source
- Leukemialymphoma. 49(12)
- Subject
- Cancer Research
Histone Deacetylases
Pathogenesis
Polycythemia vera
Medicine
Humans
Myelofibrosis
Myeloproliferative neoplasm
Myeloproliferative Disorders
business.industry
Essential thrombocythemia
Hematology
Janus Kinase 2
medicine.disease
Hematopoietic Stem Cells
HDAC4
HDAC1
Isoenzymes
Oncology
Primary Myelofibrosis
Case-Control Studies
Immunology
Mutation
Cancer research
Histone deacetylase
business
- Language
- ISSN
- 1029-2403
We measured histone deacetylase (HDAC) activity in 17 patients with primary myelofibrosis (PMF); 19 with other myeloproliferative neoplasm (MPN) and 16 normal volunteers. Significantly elevated HDAC levels were shown in patients with PMF compared with other MPN patients and normal volunteers (p