Additional file 2: Figure S1. In silico separation of tumor cells from non-tumor cell types in the scRNA-seq data. Figure S2. Identification of human cell types using well-known cell markers. Figure S3. Tumor weight change by tipifarnib treatment. Figure S4. Quality control of total cells and separation of human cells and mouse cells. Figure S5. Potential target drug resistance mechanism in tumor cell heterogeneity. Figure S6. Identification of mouse cell types using well-known cell markers. Figure S7. Identification of mouse fibroblast subtypes using well-known cell markers. Figure S8. Identification of mouse macrophage subtypes using well-known cell markers. Figure S9. Identification of mouse T cell and NK cell subtypes using well-known cell markers. Figure S10. Personalized treatment strategy after target drug resistance.