Monitoring of C-reactive protein decreases length of stay after laparoscopic total mesorectal excision for cancer: a prospective case-matched study in 236 patients
- Resource Type
- Authors
- Elisabeth Hain; Yves Panis; Antoine Cazelles; Marie Monsinjon; Massimo Giacca; A. Frontali
- Source
- Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and IrelandREFERENCES. 23(5)
- Subject
- medicine.medical_specialty
Colorectal cancer
Anastomotic Leak
Anastomosis
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
biology
business.industry
Rectal Neoplasms
C-reactive protein
Area under the curve
Cancer
Length of Stay
medicine.disease
Total mesorectal excision
C-Reactive Protein
Treatment Outcome
030220 oncology & carcinogenesis
biology.protein
Homogeneous group
030211 gastroenterology & hepatology
Laparoscopy
business
Body mass index
- Language
- ISSN
- 1463-1318
AIM The aim of this study was to evaluate a discharge strategy driven by monitoring of C-reactive protein (CRP) in a homogeneous group of patients undergoing laparoscopic total mesorectal excision with sphincter-saving surgery for rectal cancer (TME). METHOD One hundred and thirteen patients who underwent a TME had CRP monitoring on postoperative day (POD) 5. Patients were discharged on POD 6 if the CRP level was ≤100 mg/L. Patients were matched (according to age, gender, body mass index, neoadjuvant pelvic irradiation and type of anastomosis) to 123 control patients who underwent the same operation with the same postoperative care but without CRP monitoring. RESULTS Postoperative 3-month overall [CRP group 62/113 (55%) vs controls 73/123 (59%); p = 0.487] and severe (i.e. Clavien-Dindo grade 3 and above) [CRP group 17/113 (15%) vs controls 19/123 (15%); p = 0.931] morbidity rates were similar between groups. Mean length of hospital stay (LHS) was significantly shorter in the CRP group (CRP group 9.7 ± 14 days vs controls 11.6 ± 7 days; p