Additional file 1: Fig. S1. The peak area of 1H NMR was used to calculate the percentage of PTX in FA-PEG-PTX (left) and the standard absorbance curve of PRI and FA-PEG-PTX to calculate the drug-loading (right). Fig. S2. Cell viability evaluation of A549 cells treated with different concentrations of P@FPP NMs (n = 3). *: P < 0.05. **: P < 0.01. ***: P < 0.001. Fig. S3. A–B Wound healing and relative quantitative analysis of A549 cells with different treatments (n = 3). *: P < 0.05. Fig. S4. Jelly like substances of FA-PEG-COOH in the aqueous solution. Table S1. Primers using in this work for qRT-PCR analysis. Table S2. Primary antibodies used in this study for Western blot analysis.