Supplementary Figure 1. Object-based automated detection analysis of immune cell infiltration in human PCa with CellProfiler Software. Supplementary Figure 2. Automated analysis of the angiogenesis and stromal activation in PCa. Supplementary Figure 3. Automated quantification of neurogenesis, neural invasion and tumor proliferation rate in human PCa. Supplementary Figure 4. Histopathological impact of the applied pre-treatment: Gemcitabine-based therapy vs Folfirinox vs Radiochemotherapy (RTx). Supplementary Figure 5. Correlation analysis between tumor index and tumor-infiltrating immune cells, desmoplastic reaction and neural invasion. Supplementary Figure 6. Correlation analysis between ASI and tumor-infiltrating immune cells. Supplementary Figure 7. Correlation analysis between cytotoxic T cells (A, B) and Treg ratios (C,D) with angiogenesis. Supplementary Figure 8. Impact of neoTx on neurogenesis and its correlation with stromal activity. Supplementary Figure 9. Survival analysis of PCa patients based on clinical features. Supplementary Figure 10. Spatial distribution of the components of the tumor microenvironment according to the anatomical location of the tumor. Supplementary Figure 11. Immunological effects of NeoCTx in human PCa. (A) PCa-mediated immunosuppresive tumor microenvironment.