Purpose Fournier's gangrene (FG) is a polymicrobial disease that affects the skin and subcutaneous tissue and is life-threatening. This study aimed to evaluate the feasibility of scoring systems in predicting mortality in FG patients. Material and Method: 53 patients diagnosed with FG and operated between March 2008-August 2020 in our clinic were included. These patients' demographic findings, laboratory values, Fournier's Gangrene Severity Index (FGSI), Uludağ Fournier's Gangrene Severity Indexi (UFGSI), the Sequential Organ Failure Assessment (SOFA), and Age-Adjusted Charlson Comorbidity Index (ACCI) scoring system values were recorded and analyzed regarding how these scoring systems affected mortality. Results 11 (21%) of the 53 patients died, and 42 (79%) survived. The mean age of the patients was 53.64±17.2 years. The mean age of the surviving patients was 49.64±15.26 years, while the mean age of the patients who died was 68.91±15.96 (p=0.002). Of the laboratory parameters, only creatinine elevation was significant in demonstrating mortality (p=0.001). When the impact of scoring systems on mortality was evaluated, it was determined that the increase in FGSI(P=0.000), UFGSI(P=0.000), SOFA(P=0.000), and ACCI(P=0.003) values were directly related to mortality and statistically significant. Conclusion The FGSI, UFGSI, SOFA, and ACCI scoring systems used in our study were correlated with mortality for FG. ACCI had the highest diagnostic confirmation value. This was followed by SOFA, FGSI, and UFGSI, respectively. We recommend that these scoring systems be used to predict mortality for FG.