The aim of the study: to estimate the efficacy of the colorectal cancer (CRC) risk assessment according to the questionnaire and the fecal immunochemical test (FIT). The pilot study included 2,324 respondents over 40 years of age, without severe comorbidities, who filled out the original questionnaire and had the FIT. Risk stratification (high, moderate, low) was done using the original software for automatic data processing. Occult blood detection in feces was done using the fecal immunochemical test. Colonoscopy was proposed for all persons included in the screening program. The questionnaire revealed the high CRC risk in 272 (11.7 %) respondents, moderate risk — in 1,349 (58.0 %), and low risk — in 703 (30.0 %) respondents. The respondents with the high CRC risk had positive FIT results significantly more often — 199 (73.2 %) respondents, with 148 (11.0 %) respondents in the moderate-risk group, and 21 (3.0 %) respondents in the low-risk group (р