The aim of this meta-analysis study is to examine the effectiveness of various intervention programs in the promotion of sexual health knowledge / behaviors in adolescents. In the context of this research, which meta-analysis method was used, as a result of the review of literature conducted by using various databases, 28 studies were reached between the years 2007-2017, 13 of which were included meta-analysis. For the mentioned 13 intervention programs, the country / culture (individualist / collectivist) and the measured sexual health component (knowledge level / behavior) were determined as hypothetical moderator variables. The findings of the analysis using the random effect model showed that the intervention programs applied were highly effective in increasing sexual health knowledge / behaviours in adolescents. It was determined that two of the hypothetical moderator variables function as moderator variable. It was reached that the intervention programs conducted in individualist countries have improved further and programs that aim to promote healthy sexual behavior are more successful at a higher level when compared to programs that aim to promote sexual health knowledge.