Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice
- Resource Type
- ACADEMIC JOURNAL
- Wu, Mei-Ling a, 1; Yang, Xue-Qin a, 1, 2; Xue, Li a; Duan, Wei b; Du, Jun-Rong a,
- In Behavioural Brain Research 26 March 2021 402
Highlights •Age-related cognitive deficits and neuronal injury occurred in aged mice.•The gut microbiota in aged mice appeared to represent a proinflammatory phenotype.•Intestinal barrier and blood-brain barrier injuries were induced in aged mice.•LPS-activated TLR4 pathway contributed to age-related peripheral inflammation.•LPS/TLR4 pathway activation was involved in age-related neuroinflammation.