Assembly and immunogenicity of coronavirus-like particles carrying infectious bronchitis virus M and S proteins.
- Resource Type
- Article
- Authors
- Liu, Genmei; Lv, Lishan; Yin, Lijuan; Li, Xiaoming; Luo, Dongu; Liu, Kang; Xue, Chunyi; Cao, Yongchang
- Source
- Vaccine. Nov2013, Vol. 31 Issue 47, p5524-5530. 7p.
- Subject
- *IMMUNOGENETICS
*CORONAVIRUSES
*BRONCHITIS
*RECOMBINANT baculoviruses
*IMMUNE response
*COMPARATIVE studies
*LABORATORY mice
- Language
- ISSN
- 0264-410X
Highlights: [•] We generate IBV VLPs carrying M and S proteins using recombinant baculovirus. [•] The VLPs elicit humoral immune responses comparable to inactivated IBV in mice and chickens. [•] The VLPs elicit higher cellular immune responses than inactivated IBV in mice. [ABSTRACT FROM AUTHOR]