Detection and genotyping of cervical HPV with simultaneous cervical cytology in Turkish women: a hospital-based study.
- Resource Type
- Article
- Authors
- Yuce, Kunter; Pinar, Ahmet; Salman, Mehmet; Alp, Alpaslan; Sayal, Berkan; Dogan, Selen; Hascelik, Gulsen
- Source
- Archives of Gynecology & Obstetrics. Jul2012, Vol. 286 Issue 1, p203-208. 6p.
- Subject
- *PAPILLOMAVIRUSES
*CYTOLOGY
*DISEASES in women
*UNIVERSITY hospitals
*LITERATURE reviews
*DISEASE prevalence
- Language
- ISSN
- 0932-0067
Purpose: To investigate the prevalence of cervical human papilloma virus (HPV) with genotyping and simultaneous cervical cytology among Turkish women in a university hospital. A review of literature was done as well to summarize the results of similar Turkish studies based on hospital data. Methods: Women who were subjected to cervical HPV-DNA testing with simultaneous cervical Pap test were included. Seeplex HPV 18-plex Genotyping Test was used for HPV detection and typing. Liquid-based cytology was used for Pap test and Bethesda system was used for results. Results: Study group included 890 patients with a mean age of 39.5 years. The prevalence of any HPV was 25.7% while high-risk HPV was positive in 23.0%. There were no significant differences in HPV prevalence between younger and older women. Among HPV-positive women, 89.5% had at least one type of high-risk HPV. Most common HPV was type 16 followed by type 31 and 51. Abnormal cervical cytology rate was 11.6%. Rate of HPV positivity was significantly higher in women with abnormal cervical cytology compared to women with normal cytology (54.4 vs. 22.0%). Conclusions: Cervical HPV infection is a serious and gradually growing problem for Turkish women according to hospital-based data. This may be associated with low age at marriage and more sensitive HPV detection methods. [ABSTRACT FROM AUTHOR]