Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-? targeting: first in-human results.
- Resource Type
- Article
- Authors
- van Dam, Gooitzen M; Themelis, George; Crane, Lucia M A; Harlaar, Niels J; Pleijhuis, Rick G; Kelder, Wendy; Sarantopoulos, Athanasios; de Jong, Johannes S; Arts, Henriette J G; van der Zee, Ate G J; Bart, Joost; Low, Philip S; Ntziachristos, Vasilis
- Source
- Nature Medicine. Oct2011, Vol. 17 Issue 10, p1315-1319. 5p. 1 Color Photograph, 2 Diagrams, 1 Chart, 1 Graph.
- Subject
- *OVARIAN cancer
*ONCOLOGIC surgery
*PROGNOSIS
*FLUORESCENCE spectroscopy
*OPERATIVE ultrasonography
- Language
- ISSN
- 1078-8956
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-? (FR-?) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-?-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-?-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery. [ABSTRACT FROM AUTHOR]