AbstractBackground: We report here on a third case of squamous cell carcinoma (SCC) of the renal pelvis extending to the inferior vena cava. Methods/Results: A 48-year-old man was diagnosed with an advanced left renal pelvic tumor on computed tomography. He had undergone extracorporeal shock wave lithotripsy for left staghorn calculi 10 years ago. An inferior vena cavagram showed tumor thrombus extending to the inferior vena cava. Percutaneous left renal biopsy revealed SCC. The patient received three courses of combination chemotherapy with cisplatin, bleomycin and etoposide. However, 1 month after the last course of chemotherapy, he died of cancer progress. Conclusion: This is the third case of SCC of the renal pelvis extending to the inferior vena cava in the world. [ABSTRACT FROM AUTHOR]