Synthesis of 3-arylamino-2-polyhydroxyalkyl-substituted indoles from unprotected saccharides and anilines.
- Resource Type
- Article
- Authors
- Wu, Jilai; Zhou, Likai; Xie, Song; Wei, Chao; Li, Xiaoliu; Chen, Hua
- Source
- Green Chemistry. 2/21/2024, Vol. 26 Issue 4, p1883-1888. 6p.
- Subject
- *SACCHARIDES
*INDOLE compounds
*INDOLE derivatives
*AROMATIC amines
*ANILINE
*FUNCTIONAL groups
*SUGARS
- Language
- ISSN
- 1463-9262
A simple and efficient one-pot synthetic protocol has been developed for the synthesis of 3-arylamino-2-polyhydroxyalkyl-substituted indoles by using unprotected sugars and aromatic amines. The protocol is simple to carry out with high yields under mild reaction conditions, and has atom economy with a good substrate scope and functional group tolerance, providing a new alternative route for the synthesis of structurally diverse indole derivatives. [ABSTRACT FROM AUTHOR]