Evaluation of the Immune Microenvironment with Tumor Recurrence in Sinonasal Undifferentiated Carcinoma.
- Resource Type
- Article
- Authors
- Takahashi, Yoko; Gomez, Javier; Burks, Jared; Amit, Moran; Bell, Diana; Xie, Tong-Xin; Hoke, Austin; London, Nyall; Hanna, Ehab Y
- Source
- Journal of Neurological Surgery. Part B. Skull Base. 2024 Supplement, Vol. 85, pS1-S398. 398p.
- Subject
- *DISEASE relapse
*CARCINOMA
*TUMOR microenvironment
*PROGRAMMED cell death 1 receptors
*PARANASAL sinuses
*CELL communication
*CANCER relapse
- Language
- ISSN
- 2193-6331
This article, published in the Journal of Neurological Surgery, explores the immune microenvironment in relation to tumor recurrence in Sinonasal Undifferentiated Carcinoma (SNUC). SNUC is a rare and aggressive cancer that affects the nasal cavity and paranasal sinuses. The study analyzes cell-cell interactions within tumor samples from 14 SNUC patients and identifies a correlation between low-expressing CK tumor cells and CD56+ cell interactions with tumor recurrence. The findings suggest that investigating the population of CK low cells at the beginning of treatment may be important for predicting recurrence in SNUC patients. [Extracted from the article]