One-step synthesis of a dual-functional AIE-active probe for ClO− detection and photodynamic therapy.
- Resource Type
- Article
- Authors
- Liu, Yiping; Fu, Juan; Wan, Jiaxing; Huang, Tongsheng; Zhu, Weifeng; Tian, Jianwen; Liu, Meiying; Zhang, Xiaoyong; Wei, Yen
- Source
- Chemical Communications. 1/25/2024, Vol. 60 Issue 8, p984-987. 4p.
- Subject
- *PHOTODYNAMIC therapy
*REACTIVE oxygen species
*FLUORESCENT probes
*BIOMEDICAL materials
*DETECTION limit
- Language
- ISSN
- 1359-7345
An amphiphilic fluorescent probe (BHSMP) with aggregation-induced emission (AIE) features was synthesized via a one-step route. The probe showed high water dispersibility, low toxicity and the ability of selective and sensitive (limit of detection of 0.11 µM) detection of ClO− with fast-response (≤30 s) in aqueous solution and living organisms. Owing to the donor–acceptor (D–A) structure and existence of cationic groups, BHSMP could also generate reactive oxygen species under light-irradiation and potentially be utilized for photodynamic therapy. The strategy described in this work is of great significance for the design and synthesis of multifunctional AIE-active functional materials to facilitate their biomedical applications. [ABSTRACT FROM AUTHOR]