Objective: To explore the efficacy of Cangfu Daotan Pill on phlegm dampness type polycystic ovary syndrome (PCOS) and its influence on the phosphatidylinositol-3-kinase (PI3K) /protein kinase B (AKT) signaling pathway in peripheral blood. Methods: 86patients with phlegm dampness type PCOS who were admitted to Cangzhou Integrated Traditional Chinese and Western Medicine Hospital of Hebei Province from January 2022 to October 2022 were included. According to the random number table method, they were divided into control group (n=43, treated with Diane-35) and experimental group (n=43, treated with Diane-35 combined with Cangfu Daotan Pill) . The traditional Chinese medicine syndrome scores, sex hormone indicators, glucose and lipid metabolism indicators,PI3K/AKT signaling pathway related indicators changes and the incidence of adverse reactions were observed in two groups. Results:Compared with control group after treatment, experimental group had lower traditional Chinese medicine syndrome scores, triglyceride (TG), follicle stimulating hormone (FSH), low-density lipoprotein cholesterol (LDL-C), testosterone (T), luteinizing hormone (LH), fasting blood glucose (FBG), total cholesterol (TC), fasting insulin (FINS) levels and lower PI3K messenger ribonucleic acid (m RNA), AKT m RNA, and higher high-density lipoprotein cholesterol (HDL-C) (P<0.05) . There was no difference in the incidence of adverse reactions between two groups (P>0.05) . Conclusion: Cangfu Daotan Pill is used to treat patients with phlegm dampness type PCOS, which can effectively regulate sex hormones and glucose and lipid metabolism indicators, improve clinical symptoms, may be related to regulating the PI3K/AKT signaling pathway in peripheral blood. [ABSTRACT FROM AUTHOR]