This article discusses a study that aimed to characterize the endothelial cells in esophageal squamous cell carcinoma (ESCC) and their potential implications for anti-angiogenic therapies. The researchers performed single-cell sequencing on cells from different regions of ESCC tumors and matched normal esophageal tissues. They identified distinct cell lineages and found that the composition of these lineages varied across the tumor and peri-tumoral tissue. The study also revealed the presence of angiogenic tumor endothelial cells (TECs) in ESCC, which expressed genes associated with collagen modification, angiogenesis, and vascular endothelial growth factor (VEGF) signaling. The findings suggest that targeting these angiogenic TECs could be a promising therapeutic strategy for ESCC. Additionally, the study compared the endothelial cell phenotypes between ESCC and non-small cell lung cancer (NSCLC) and found a significant transcriptome overlap of angiogenic endothelial cells in both tumor types. The results provide insights into the geospatial architecture and therapeutic targets of endothelial cells in ESCC and highlight the potential clinical implications of anti-angiogenic therapies. [Extracted from the article]